Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps3-23-02 | Pregnancy | ETA2023

B cells from anti-thyroid antibody positive, infertile women show hyper-reactivity to BCR stimulation

Bajnok Anna , Sereny-Litvai Timea , Temesfoi Viktoria , Norenberg Jasper , Pham-Dobor Greta , Kaposi Ambrus , Varnagy Akos , Kovacs Kalman , Pentek Sandor , Koszegi Tamas , Berki Timea , Mezosi Emese

Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca2+) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca2+ flux response of B lymphocyte subsets to BCR stimulation in Hashimoto’s thyroiditis and related infertility. We collected peripheral blood samples from ATA+, in...